Chromosomal Changes in B-cell Non-Hodgkin's Lymphoma
Author Information
Author(s): Stokke T, DeAngelis P, Smedshammer L, Galteland E, Steen H B, Smeland E B, Delabie J, Holte H
Primary Institution: The Norwegian Radium Hospital
Hypothesis
Loss of certain chromosomes and gain of others are independent prognostic indicators in B-cell non-Hodgkin's lymphoma.
Conclusion
Loss of chromosome 11q21–23.1 and 17p, along with gain of chromosome 6p, are significant indicators of poor prognosis in B-cell non-Hodgkin's lymphoma.
Supporting Evidence
- A high number of chromosomal aberrations was linked to shorter survival.
- Loss of specific chromosomes was associated with different lymphoma subtypes.
- Gains in certain chromosomes were more frequent in specific types of lymphoma.
Takeaway
This study found that changes in specific chromosomes can help predict how well patients with a type of blood cancer will do.
Methodology
Comparative genomic hybridization (CGH) was used to analyze chromosomal aberrations in B-cell non-Hodgkin's lymphoma cases.
Participant Demographics
Patients diagnosed with B-cell non-Hodgkin's lymphoma between 1983 and 1993.
Statistical Information
P-Value
P ≤ 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website