Review of Family-Based Tests for Genetic Linkage Disequilibrium
Author Information
Author(s): Ewens Warren J., Li Mingyao, Spielman Richard S.
Primary Institution: University of Pennsylvania
Hypothesis
What are the properties of the various Allison/Abecasis regression-based tests and the Rabinowitz and the Monks-Kaplan tests?
Conclusion
The review outlines the features and relationships of various quantitative transmission/disequilibrium tests used in genetic studies.
Supporting Evidence
- The review discusses the properties of various quantitative TDT procedures.
- It highlights the relationships between different testing procedures.
- The review addresses power considerations in choosing the appropriate test.
Takeaway
This study looks at different tests that help scientists understand how genes might be linked to traits in families. It explains how these tests work and what they can tell us.
Methodology
The review discusses various quantitative TDT procedures and their properties, focusing on family trio data.
Potential Biases
The review notes potential issues with population stratification affecting regression-based tests.
Limitations
The review does not cover all quantitative TDT procedures and focuses only on family trios.
Participant Demographics
The study focuses on family trios, which consist of a mother, a father, and one child.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website