Reevaluating Intraamniotic Infection During Amniocentesis
Author Information
Author(s): Peter H. Cherouny, Glenn A. Pankuch, John J. Botti
Primary Institution: University of Vermont and Pennsylvania State University
Hypothesis
What is the incidence of occult early midtrimester intraamniotic infection in asymptomatic patients at the time of genetic amniocentesis?
Conclusion
The incidence of occult intraamniotic infection in the second trimester is lower than previously reported.
Supporting Evidence
- All amniotic fluid specimens tested negative for bacteria and bioactive leukoattractants.
- The study found a significantly lower incidence of infection compared to previous reports.
- Two samples showed artifacts resembling spermatozoa, a previously unreported finding.
Takeaway
Doctors checked the fluid from pregnant women for germs during a test called amniocentesis, and they found very few germs, which means the risk of infection is low.
Methodology
Amniotic fluid specimens were collected and tested for bacteria and bioactive leukoattractants using microscopy and cultures.
Limitations
The study may not account for all possible infections or variations in patient populations.
Participant Demographics
Patients with viable singleton pregnancies referred for amniocentesis, primarily due to advanced maternal age.
Statistical Information
P-Value
0.002
Confidence Interval
95% CI, 0-1.9%; 99% CI, 0-2.9%
Statistical Significance
p<0.05
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