Impact of Bisphenol S on Gut Microbiota in Mice
Author Information
Author(s): A. Cox, Nowshad Farrhin, Callaway Evelyn, Jayaraman Arul
Primary Institution: Texas A&M University
Hypothesis
What is the effect of Bisphenol S on the gut microbiota of C57BL/6 mice?
Conclusion
The study found that Bisphenol S exposure did not significantly alter the gut microbiota composition or metabolome in mice.
Supporting Evidence
- BPS exposure did not produce a distinct microbial profile compared to controls.
- Several metabolites, including saturated fatty acids, were enriched in BPS-exposed cultures.
- Lactobacillus species were associated with BPS exposure in a discriminant model.
Takeaway
This study looked at how a chemical called Bisphenol S affects tiny living things in the stomach of mice, and it found that it didn't really change much.
Methodology
The study used shotgun metagenomic sequencing and untargeted LC-MS/MS metabolomic analysis on murine fecal cultures exposed to Bisphenol S.
Potential Biases
Potential bias due to the use of a supraphysiologic dose and the in vitro model not fully representing in vivo conditions.
Limitations
Inter-animal variation was significant, and the lack of an acclimation phase for the microbiota may have affected results.
Participant Demographics
Female C57BL/6 mice were used in the study.
Statistical Information
P-Value
0.605 for metabolomics, 0.989 for metagenomics
Statistical Significance
p=0.605 for metabolomics, p=0.989 for metagenomics
Digital Object Identifier (DOI)
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