Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells
2006
Nutritional and Chemopreventive Agents Increase p27 Expression in Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): Eto Isao
Primary Institution: University of Alabama at Birmingham
Hypothesis
Do various nutritional and chemopreventive anti-cancer agents up-regulate the expression of p27 in preneoplastic and neoplastic cells?
Conclusion
Various nutritional and chemopreventive anti-cancer agents up-regulate expression of p27 in (pre)neoplastic cells.
Supporting Evidence
- Up-regulation of p27 is likely due to activation of translation rather than transcription.
- Caloric restriction and amino acid deficiencies can increase p27 expression.
- Different signaling pathways are involved in the up-regulation of p27 by nutritional agents.
Takeaway
Certain foods and supplements can help cancer cells grow slower by increasing a protein called p27.
Methodology
The study used transient transfection assays to investigate the effects of various agents on the p27 gene's activity.
Digital Object Identifier (DOI)
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