ACE2 and Pyroptosis in Traumatic Brain Injury
Author Information
Author(s): Guo Jinxiu, Zhao Shiyuan, Chu Xue, Wang Changshui, Meng Junjun, Wei Shanshan, Wang Jianhua, Guo Yujin, Kong Weihua, Sun Wenxue, Zhang Tao, Dang Ruili, Yang Mengqi, Chen Jing, Jiang Pei
Primary Institution: Jining First People's Hospital, Shandong First Medical University
Hypothesis
Can ACE2 modulation influence the pyroptosis pathway in traumatic brain injury?
Conclusion
The study suggests that ACE2 deficiency exacerbates pyroptosis and inflammation in traumatic brain injury, while ACE2 modulation may offer neuroprotective effects.
Supporting Evidence
- ACE2 levels significantly decreased in the injured cortical area after traumatic brain injury.
- AVE0991 treatment improved cognitive and motor functions in TBI mice.
- Transcriptome sequencing revealed significant changes in pyroptosis-related genes following ACE2 depletion.
Takeaway
This study looks at how a protein called ACE2 can help protect the brain after an injury by stopping a harmful process called pyroptosis.
Methodology
The study used animal models to investigate the effects of ACE2 modulation on pyroptosis and inflammation following traumatic brain injury.
Digital Object Identifier (DOI)
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