Genetic Factors Influencing Blood Pressure Variation
Author Information
Author(s): Lin Jennifer, Hinrichs Anthony, Suarez Brian K
Primary Institution: Brigham and Women's Hospital, Harvard Medical School
Hypothesis
There is a heritable component to intra-individual variation in systolic blood pressure.
Conclusion
Genomic regions near specific markers may regulate systolic blood pressure homeostasis.
Supporting Evidence
- Moderate familial resemblance for blood pressure variability was observed.
- Linkage analysis revealed multiple significant genomic regions.
- Two genomic regions were replicated in a second cohort.
Takeaway
This study looked at how family genes might affect blood pressure changes over time, finding some important areas in our DNA that could be linked to this.
Methodology
The study used multipoint quantitative linkage analysis on data from the Framingham Heart Study.
Potential Biases
The relationship between medication usage and blood pressure variability may have confounded the results.
Limitations
The analysis was limited by the small size of Cohort 1 and the lack of adjustment for body mass index.
Participant Demographics
Participants were from the Framingham Heart Study, with a focus on individuals with multiple blood pressure measurements.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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