Role of Fra-1 in Breast Cancer Progression
Author Information
Author(s): Angela Logullo, Mônica Maria Ágata Stiepcich, Cintia Aparecida Bueno de Toledo Osório, Sueli Nonogaki, Fátima Solange Pasini, Rafael Malagoli Rocha, Fernando Augusto Soares, Maria M Brentani
Primary Institution: Universidade de São Paulo
Hypothesis
The study aims to evaluate the role of Fra-1 expression in breast carcinoma progression and prognosis.
Conclusion
Fra-1 expression is associated with aggressive features in invasive ductal carcinoma but does not correlate with overall survival.
Supporting Evidence
- Fra-1 positivity was found in 22.8% of IDC cases and 42.2% of DCIS cases.
- Fra-1 expression correlated with high grade and HER-2 positivity in IDC.
- No significant association was found between Fra-1 and survival in IDC.
Takeaway
Fra-1 is a protein that can indicate how aggressive a breast cancer might be, but having more of it doesn't mean a patient will live longer.
Methodology
Immunohistochemistry was used to analyze Fra-1 expression in tissue microarrays of ductal carcinoma in situ and invasive ductal carcinoma samples.
Limitations
The study is retrospective and does not include a paired analysis of DCIS and IDC cases.
Participant Demographics
{"median_age":{"DCIS":50.5,"IDC":56},"gender":"female"}
Statistical Information
P-Value
0.001, 0.015, 0.004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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