SULT1A1 Polymorphism and Cancer Risk
Author Information
Author(s): Kotnis A, Kannan S, Sarin R, Mulherkar R
Primary Institution: Tata Memorial Centre, Navi Mumbai, India
Hypothesis
If tobacco carcinogenesis is significantly modulated by the Arg213His polymorphism, it would demonstrate a significant association with tobacco-related cancers.
Conclusion
The SULT1A1 Arg213His polymorphism is associated with increased risk of tobacco-related upper aerodigestive tract cancers, particularly in Asian women for breast cancer.
Supporting Evidence
- SULT1A1*2 showed significant risk association with upper aerodigestive tract multiple primary neoplasms.
- Meta-analysis included 34 studies with over 11,000 cancer cases.
- The His213 allele frequency was significantly lower in Asians compared to Caucasians.
Takeaway
This study found that a specific gene change can increase the risk of certain cancers related to tobacco, especially in different ethnic groups.
Methodology
A case-control study with 132 patients and 198 cancer-free controls, followed by a meta-analysis of 34 studies.
Potential Biases
Potential publication bias was assessed but not found significant.
Limitations
The study's findings may be influenced by ethnic differences and the complexities of confounding variables.
Participant Demographics
Majority of participants were from western and northern India, with a mix of tobacco users and cancer-free controls.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 1.09, 27.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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