Humanized Mouse Model for Ovarian Cancer
Author Information
Author(s): Bankert Richard B., Balu-Iyer Sathy V., Odunsi Kunle, Shultz Leonard D., Kelleher Raymond J. Jr., Barnas Jennifer L., Simpson-Abelson Michelle, Parsons Robert, Yokota Sandra J.
Primary Institution: The State University of New York, University at Buffalo
Hypothesis
Can a humanized mouse model effectively replicate the progression and metastasis of ovarian cancer observed in patients?
Conclusion
The study successfully developed a humanized mouse model that closely mimics the progression and metastasis of ovarian cancer seen in patients.
Supporting Evidence
- The model allows for the study of tumor-associated lymphocytes and fibroblasts in the tumor microenvironment.
- Tumor growth and metastasis patterns in the mice closely reflect those observed in ovarian cancer patients.
- CA125 levels in the mice can be monitored, similar to how it is used in patients.
Takeaway
Researchers created a special mouse model that helps them study how ovarian cancer grows and spreads, just like it does in people.
Methodology
Ovarian tumor cell aggregates were injected into NSG mice to establish xenografts that mimic human ovarian cancer.
Limitations
The model may not fully capture all aspects of human ovarian cancer due to the inherent differences between species.
Participant Demographics
Tumor samples were derived from five different ovarian cancer patients.
Digital Object Identifier (DOI)
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