Study of hAG-2 and hAG-3 in Breast Cancer
Author Information
Author(s): Fletcher G C, Patel S, Tyson K, Adam P J, Schenker M, Loader J A, Daviet L, Legrain P, Parekh R, Harris A L, Terrett J A
Primary Institution: Oxford Glycosciences
Hypothesis
hAG-2 and hAG-3 are associated with oestrogen receptor-positive breast tumours and interact with metastasis-related proteins.
Conclusion
hAG-2 and hAG-3 are coexpressed in breast cancer tissues and may play a role in tumor establishment and metastasis.
Supporting Evidence
- hAG-2 and hAG-3 mRNA and protein exhibit a similar expression pattern in breast cancer tissues.
- Coexpression of hAG-2 and hAG-3 correlates with oestrogen receptor status.
- Both proteins interact with C4.4a and alpha-dystroglycan, which are associated with metastasis.
Takeaway
This study found that two proteins, hAG-2 and hAG-3, are often found together in breast cancer and might help the cancer spread.
Methodology
Immunohistochemical and real-time quantitative RT–PCR analysis were used to assess the expression of hAG-2 and hAG-3 in breast cancer tissues.
Limitations
The study did not assess the role of hAG-2 and hAG-3 in lymph node metastasis.
Participant Demographics
Breast cancer tissues from 60 donors were analyzed.
Statistical Information
P-Value
P<0.0001 for coexpression of hAG-2 and hAG-3
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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