New Sensor for Detecting Alpha-Fetoprotein Levels
Author Information
Author(s): Su Xiaoyu, Chen Junbiao, Wu Shanshan, Qiu Yong, Pan Yuxiang
Primary Institution: Zhejiang University
Hypothesis
Can a novel electrochemical aptamer sensor improve the detection of alpha-fetoprotein (AFP) levels?
Conclusion
The developed sensor shows high sensitivity and selectivity for AFP detection, making it suitable for clinical applications.
Supporting Evidence
- The sensor demonstrated a log-linear relationship for AFP detection in the range of 1–300 ng/mL.
- The limit of detection (LOD) for the sensor was found to be 0.05 ng/mL.
- The sensor showed satisfactory selectivity against common interfering biomolecules.
- The reproducibility of the sensor was confirmed with a relative standard deviation of 5.7%.
- The sensor maintained acceptable long-term stability with less than 8.4% signal fluctuation over seven days.
Takeaway
Scientists created a new sensor that can quickly and accurately measure a substance called alpha-fetoprotein, which helps doctors check for liver cancer.
Methodology
The sensor was developed using AuNPs–MXene composite materials and tested with various concentrations of AFP in both laboratory and clinical samples.
Limitations
The sensor's portability and real-time analysis capabilities are currently limited.
Digital Object Identifier (DOI)
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