Impact of Surgery on Breast Cancer Micrometastases

Sample size: 1423 publication Evidence: moderate

Author Information

Author(s): Demicheli R, Valagussa P, Bonadonna G

Primary Institution: Istituto Nazionale Tumori

Does surgery modify growth kinetics of breast cancer micrometastases?

Surgery may significantly affect the development of metastases in breast cancer patients.

Surgery should be considered as a major perturbing factor for metastasis development in laboratory animals.
The different time distribution of mortality for 1173 patients undergoing mastectomy in comparison with 250 untreated patients suggests that primary tumour removal could result in changes of the metastatic process.

Removing a breast tumor might change how cancer spreads in the body.

Comparison of mortality rates between patients undergoing mastectomy and untreated patients.

1173 patients undergoing mastectomy and 250 untreated patients.

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