Association between Plasma Antibody Response and Protection in Rainbow Trout Oncorhynchus mykiss Immersion Vaccinated against Yersinia ruckeri
2011

Rainbow Trout Vaccination Against Yersinia ruckeri

Sample size: 800 publication Evidence: high

Author Information

Author(s): Raida Martin K., Nylén Jørgen, Holten-Andersen Lars, Buchmann Kurt

Primary Institution: Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark

Hypothesis

Is there an association between the production of specific antibodies against Yersinia ruckeri and the protection in immersion vaccinated rainbow trout?

Conclusion

The study found that immersion vaccination significantly increased antibody levels and reduced mortality in rainbow trout challenged with Yersinia ruckeri.

Supporting Evidence

  • All immersion vaccinated groups showed 0% mortality when challenged with Y. ruckeri.
  • The mortality in the sham-vaccinated control group was 40% and 28% at 8 and 26 weeks post vaccination, respectively.
  • A significant increase in Y. ruckeri specific IgM antibody levels was recorded in vaccinated fish.

Takeaway

The study shows that giving a special vaccine to rainbow trout helps them fight off a harmful bacteria, keeping them safe and healthy.

Methodology

Rainbow trout were immersion-vaccinated and then challenged with Yersinia ruckeri to assess protection and antibody response.

Limitations

The study may not fully represent field conditions where stress and bacterial load can vary significantly.

Participant Demographics

Rainbow trout (Skinderup strain from Jutland, Denmark), average body weight of 25±3 g.

Statistical Information

P-Value

p<0.0001

Statistical Significance

p<0.0001

Digital Object Identifier (DOI)

10.1371/journal.pone.0018832

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