Inflammatory Response in Elderly Patients After Hernioplasty
Author Information
Author(s): Di Vita Gaetano, Balistreri Carmela Rita, Arcoleo Francesco, Buscemi Salvatore, Cillari Enrico, Donati Marcello, Garofalo Maria, Listì Florinda, Grimaldi Maria Paola, Patti Rosalia, Candore Giuseppina
Primary Institution: Università di Palermo, Italy
Hypothesis
Does the acute phase response to surgical stress differ between old and young individuals?
Conclusion
Elderly patients show a stronger and prolonged inflammatory response to surgical stress compared to younger patients.
Supporting Evidence
- Elderly patients showed prolonged inflammatory activity compared to younger subjects.
- Neutrophilia was significantly higher in old patients at 6 and 24 hours post-operation.
- CRP and AAT levels increased significantly in elderly patients at 24 and 48 hours post-operation.
- TNF-α levels were significantly higher in older patients than in younger at 6 and 24 hours post-operation.
- IL-1β levels increased significantly in old patients at 6 hours post-operation.
Takeaway
Older people react more strongly to surgery than younger people, which might make them more likely to have complications afterward.
Methodology
The study measured changes in inflammatory markers in 24 male patients undergoing hernioplasty, divided into young and old groups.
Potential Biases
Potential bias due to the exclusion of patients with certain health conditions.
Limitations
The sample size was relatively small, which may have affected the significance of some results.
Participant Demographics
24 male patients, 12 aged < 61 years and 12 aged > 76 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website