Effects of Neonatal Inflammation on Blood-Brain Barrier and Behavior in Rats
Author Information
Author(s): H. B. Stolp, P. A. Johansson, M. D. Habgood, K. M. Dziegielewska, N. R. Saunders, C. J. Ek
Primary Institution: University of Melbourne
Hypothesis
Does neonatal systemic inflammation affect blood-brain barrier permeability and behavior in juvenile and adult rats?
Conclusion
Neonatal inflammation can lead to long-term changes in blood-brain barrier permeability and behavior in later life.
Supporting Evidence
- LPS treatment increased blood-brain barrier permeability in adult rats.
- Behavioral tests showed altered responses in juvenile and adult rats exposed to LPS.
- Claudin-5 distribution was altered in LPS-treated animals, indicating changes in tight junction integrity.
Takeaway
When baby rats get sick, it can change how their brains work and how they behave when they grow up.
Methodology
The study involved LPS injections in neonatal rats and subsequent behavioral tests and blood-brain barrier permeability measurements.
Limitations
The study's results may not be directly comparable across different age groups due to varying methods used for measuring permeability.
Participant Demographics
Sprague-Dawley rats, both male and female.
Statistical Information
P-Value
0.0003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website