Bacillus amyloliquefaciens and Intestinal Health
Author Information
Author(s): Chen Xing, Zheng Aijuan, Li Shuzhen, Wang Zedong, Chen Zhimin, Chen Jiang, Zou Zhiheng, Liang Haijun, Liu Guohua, Zoidis Evangelos
Primary Institution: Chinese Academy of Agriculture Sciences
Hypothesis
This study investigates how Bacillus amyloliquefaciens alleviates lipopolysaccharide (LPS)-induced intestinal oxidative stress.
Conclusion
Bacillus amyloliquefaciens JF improves oxidative stress response and intestinal health by regulating the Keap1/Nrf2 signaling pathway.
Supporting Evidence
- Bacillus amyloliquefaciens significantly decreased DPPH free radical levels and hydrogen peroxide.
- It enhanced total antioxidant capacity and reduced malondialdehyde content in Caco-2 cells.
- JF increased mRNA expression of antioxidant genes while decreasing inflammatory markers.
- In broiler chickens, JF improved antioxidant enzyme levels and reduced inflammation.
- JF enhanced intestinal barrier function by increasing tight junction protein expression.
Takeaway
Bacillus amyloliquefaciens helps keep our intestines healthy by fighting off stress and inflammation caused by bad bacteria.
Methodology
The study involved Caco-2 cells and broiler chickens, with treatments including control, LPS, Bacillus amyloliquefaciens, and a combination of both.
Participant Demographics
240 one-day-old Arbor Acres broiler chickens and human colorectal adenocarcinoma (Caco-2) cells.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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