Activation of cyclin D1-related kinase in human lung adenocarcinoma
1999
Cyclin D1-Related Kinase Activation in Lung Adenocarcinoma
publication
Author Information
Author(s): Igarashi K, Masaki T, Shiratori Y, Rengifo W, Nagata T, Hara K, Oka T, Nakajima J, Hisada T, Hata E, Omata M
Primary Institution: University of Tokyo
Hypothesis
This study aims to clarify mechanisms related to cyclin D1 involvement in the malignant transformation of non-small-cell lung cancer (NSCLC).
Conclusion
The study shows that cyclin D1-related kinases are activated in lung adenocarcinoma, suggesting their role in cancer progression.
Supporting Evidence
- Cyclin D1 gene amplification is rarely found in non-small-cell lung cancer.
- This study is the first to show activation of cyclin D1-related kinases in NSCLC.
Takeaway
The study found that a specific protein related to cancer, called cyclin D1, is more active in a type of lung cancer called adenocarcinoma, which might help it grow.
Digital Object Identifier (DOI)
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