OxyGene: A New Tool for Studying Oxidative Stress Genes in Microbes
Author Information
Author(s): Thybert David, Avner Stéphane, Lucchetti-Miganeh Céline, Chéron Angélique, Barloy-Hubler Frédérique
Primary Institution: CNRS UMR 6026, Université de Rennes 1
Hypothesis
OxyGene aims to improve the annotation of oxidative stress response genes in prokaryotic genomes.
Conclusion
OxyGene enables the exploration and comparative analysis of enzymes belonging to 37 detoxification subclasses in 664 microbial genomes.
Supporting Evidence
- OxyGene re-annotated all complete Bacterial and Archaeal genomes.
- The platform proposes a new classification for detoxification enzymes.
- OxyGene is freely available for academic use.
Takeaway
OxyGene is a tool that helps scientists find and understand genes that protect bacteria from damage caused by harmful molecules.
Methodology
OxyGene integrates a database (OxyDB) and an annotator for detecting ROS/RNS response genes in prokaryotic genomes.
Limitations
The study may not cover all possible oxidative stress response genes due to the limited number of sequenced genomes.
Digital Object Identifier (DOI)
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