Immunogenicity of a New Rabies Vaccine in Foxes and Skunks
Author Information
Author(s): Conzelmann Karl-Klaus, Finke Stefan, Müller Thomas, Teifke Jens, Fooks Anthony R., Neubert Andreas
Primary Institution: IDT Biologika GmbH
Hypothesis
Is the SAD dIND1 vaccine more immunogenic than the parental SAD B19 vaccine strain in foxes and skunks?
Conclusion
The SAD dIND1 vaccine protected foxes against rabies but failed to induce immunity in skunks.
Supporting Evidence
- Foxes vaccinated with SAD dIND1 survived rabies challenge.
- Skunks did not develop virus neutralizing antibodies after vaccination with SAD dIND1.
- Previous studies indicated that SAD B19 vaccine was more effective in skunks.
Takeaway
A new rabies vaccine worked well for foxes but didn't help skunks at all.
Methodology
Foxes and skunks were vaccinated with the SAD dIND1 vaccine and then challenged with rabies virus to assess immunogenicity.
Limitations
The small sample size of skunks limited the ability to draw strong conclusions.
Participant Demographics
The study involved captive bred foxes and skunks from commercial sources.
Digital Object Identifier (DOI)
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