A FERM-adjacent (FA) region defines a subset of the 4.1 superfamily and is a potential regulator of FERM domain function
2006
FERM-adjacent region and its role in FERM domain function
publication
Evidence: moderate
Author Information
Author(s): Baines Anthony J
Primary Institution: Department of Biosciences, University of Kent
Hypothesis
Does the FERM-adjacent region regulate the activities of its neighboring FERM domain?
Conclusion
The FERM-adjacent region defines a subset of the FERM proteins in animals and may play a regulatory role.
Supporting Evidence
- The FERM-adjacent region is conserved in about half of all other FERM-adjacent regions.
- Phylogenetic analyses indicate that all proteins containing a FERM-adjacent region arose from a single ancestor.
- PKC and PKA phosphorylate serine residues in the FERM-adjacent region, which may regulate FERM domain activity.
Takeaway
There is a special part of certain proteins that helps them work better with their neighbors, and this part is found next to a specific protein domain.
Methodology
Phylogenetic analyses and sequence alignment were used to identify and characterize the FERM-adjacent region.
Limitations
The structure of the FA region cannot be predicted with certainty due to lack of known sequences in the Protein Data Bank.
Digital Object Identifier (DOI)
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