Role of a proteolysis-inducing factor (PIF) in cachexia induced by a human melanoma (G361)
1999
Role of a proteolysis-inducing factor in cachexia induced by melanoma
Sample size: 20
publication
Evidence: high
Author Information
Author(s): Todorov P T, Field W N, Tisdale M J
Primary Institution: Pharmaceutical Sciences Institute, Aston University
Hypothesis
The study investigates the role of a proteolysis-inducing factor (PIF) produced by human melanoma in causing cachexia.
Conclusion
The study concludes that the depletion of lean body mass in mice with G361 melanoma is due to the production of PIF.
Supporting Evidence
- The G361 melanoma produces a proteolysis-inducing factor that is similar to one found in another tumor.
- Administration of PIF to mice resulted in significant weight loss without affecting food or water intake.
- Body composition analysis indicated a decrease in non-fat carcass mass.
Takeaway
Mice with a type of skin cancer lost weight because of a special factor made by the cancer, even though they still ate and drank normally.
Methodology
The study involved biosynthetic labeling of G361 cells and administration of PIF to female NMRI mice to observe weight changes.
Participant Demographics
Female NMRI mice, approximately 20 grams in weight.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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