Effects of Pasteurized Yoghurt on Gastric Ulcer in Rats
Author Information
Author(s): Ajayi O.V., Omolaso B.O., Omayone T.P., Adeniran A.G., Adu A.O., Olorunfemi O.E.
Primary Institution: University of Medical Sciences, Ondo City, Ondo State, Nigeria
Hypothesis
Does pre-treatment with pasteurized yoghurt have anti-inflammatory and anti-oxidative effects in indomethacin-induced gastric ulceration in male Wistar rats?
Conclusion
Pasteurized yoghurt significantly reduces inflammation and oxidative stress in gastric ulceration induced by indomethacin in rats.
Supporting Evidence
- Yoghurt treatment significantly decreased inflammatory markers compared to the indomethacin group.
- Histological observations showed less damage in the stomachs of rats treated with yoghurt.
- Yoghurt improved antioxidant enzyme levels in the stomach tissues of treated rats.
- Total antioxidant capacity was significantly higher in the yoghurt-treated groups compared to the indomethacin group.
Takeaway
Feeding rats yoghurt helped protect their stomachs from damage caused by a drug that usually causes ulcers.
Methodology
Thirty male Wistar rats were divided into five groups and treated with different substances for 14 days before inducing gastric ulcers with indomethacin.
Limitations
The disease model used can only detect cytoprotective action and cannot be used for ulcer healing.
Participant Demographics
Male Wistar rats, weighing 100-150g.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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