Linkage Analysis of Body Mass Index in the Framingham Heart Study
Author Information
Author(s): Li Xiaohui, Wang Dai, Yang Kai, Guo Xiuqing, Lin Ying-chao, Samayoa Carlos G, Yang Huiying
Primary Institution: Cedars-Sinai Medical Center
Hypothesis
To evaluate linkage evidence for body mass index (BMI) using both cross-sectional and longitudinal data.
Conclusion
The study found a consistent linkage for BMI on chromosome 16, suggesting it may influence BMI more during early adulthood.
Supporting Evidence
- The maximum LOD score for BMI was consistently observed on chromosome 16.
- Suggestive linkages were also found on chromosomes 6, 10, and 18 at time point 1.
- The longitudinal measure did not provide greater power to identify linkages than cross-sectional measures.
Takeaway
This study looked at how genes might affect body weight over time, finding that some genes are more important when people are younger.
Methodology
Genome-wide multipoint linkage analyses were performed on subjects with complete data at four time points.
Limitations
The study's findings may not be generalizable due to the specific sample selection criteria.
Participant Demographics
The analyzed sample included 1502 subjects from 291 pedigrees, with 808 females and 694 males, mean age approximately 40 years at time point 1.
Digital Object Identifier (DOI)
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