Impact of Peritoneal Cytology on Survival in Endometrial Cancer
Author Information
Author(s): Tebeu P M, Popowski G Y, Verkooijen H M, Casals J, Lüdicke F, Zeciri G, Usel M, Bouchardy C, Major A L
Primary Institution: Geneva University Hospitals
Hypothesis
Does positive peritoneal cytology affect the survival of endometrial cancer patients treated with surgery and radiotherapy?
Conclusion
Positive peritoneal cytology does not independently affect survival in endometrial cancer patients treated with surgery and radiotherapy.
Supporting Evidence
- Patients with cytological stage IIIA had a 5-year disease-specific survival rate of 94%.
- Patients with histological stage IIIA had a significantly lower 5-year disease-specific survival rate of 51%.
- The study included 170 patients, representing about 50% of all endometrial cancer patients treated in the public sector during the study period.
- Positive peritoneal cytology did not significantly change survival outcomes compared to stage I cancer.
- Statistical analyses were performed using the Kaplan–Meier method and Cox's proportional-hazards regression.
Takeaway
This study found that women with endometrial cancer and positive peritoneal cytology have similar survival rates to those whose cancer is confined to the uterus.
Methodology
The study included women who underwent surgery and radiotherapy for endometrial cancer, analyzing survival rates based on peritoneal cytology results.
Potential Biases
Patients were selected based on receiving radiotherapy, which may introduce selection bias.
Limitations
The study excluded patients without peritoneal cytology assessment and had a relatively low statistical power due to the limited number of patients.
Participant Demographics
The mean age of participants was 64.7 years, with a mix of stages and treatment types.
Statistical Information
P-Value
0.008
Confidence Interval
95% CI 0.3–2.0
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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