Improving Care of Acute Lung Injury Patients (ICAP) Study
Author Information
Author(s): Dale M Needham, Cheryl R Dennison, David W Dowdy, Pedro A Mendez-Tellez, Nancy Ciesla, Sanjay V Desai, Jonathan Sevransky, Carl Shanholtz, Daniel Scharfstein, Margaret S Herridge, Peter J Pronovost
Primary Institution: Johns Hopkins University
Hypothesis
What is the impact of lower tidal volume ventilation and other critical care therapies on the long-term outcomes of ALI/ARDS survivors?
Conclusion
The ICAP study aims to improve understanding of the long-term impact of ALI/ARDS and critical care management on patient outcomes.
Supporting Evidence
- The study is expected to enroll 520 patients over two years, which is more than double the sample size of previous studies.
- The study will assess outcomes including mortality, organ impairment, functional status, and quality of life.
- A multi-faceted retention strategy will be used to minimize participant loss to follow-up.
Takeaway
This study is looking at how different treatments for lung injury affect patients after they leave the hospital, to help doctors do a better job in the future.
Methodology
A multi-site, prospective cohort study enrolling mechanically ventilated ALI/ARDS patients from 11 ICUs, assessing outcomes at 3, 6, 12, and 24 months.
Potential Biases
Potential for residual confounding and bias due to non-random assignment of ICU therapies.
Limitations
The study may be subject to confounding by indication and may not generalize to all ALI/ARDS survivors due to being conducted in a single city.
Participant Demographics
Consecutive mechanically ventilated ALI/ARDS patients from 11 ICUs at four hospitals in Baltimore, MD.
Statistical Information
P-Value
p<0.05
Digital Object Identifier (DOI)
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