Serum Biomarkers of Endoplasmic Reticulum Stress in Type 2 Diabetes
Author Information
Author(s): Villafan-Bernal José Rafael, Barajas-Olmos Francisco, Guzmán-Guzmán Iris Paola, Martínez-Hernández Angélica, Contreras-Cubas Cecilia, García-Ortiz Humberto, Morales-Rivera Monserrat I., Martínez-Portilla Raigam Jafet, Orozco Lorena, Vestuto Vincenzo, Pepe Giacomo
Primary Institution: Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Hypothesis
Few biomarkers of ERS are consistently increased in humans with T2D and correlate with metabolic and anthropometric variables.
Conclusion
Six ERS biomarkers are consistently elevated in human T2D and correlate with glycemic control, insulin resistance, and β-cell function.
Supporting Evidence
- Subjects with T2D had higher circulating levels of HSP70 and secretagogin compared to controls.
- Secretagogin inversely correlated with HOMA-IR and positively correlated with HOMA-B, HbA1c, and FPG.
- PRX4 negatively correlated with HbA1c and FPG.
- HSP70 positively correlated with HbA1c.
- Most studies included were of high quality according to the Newcastle–Ottawa scale.
- Six ERS biomarkers were consistently elevated in T2D patients.
Takeaway
This study found that certain proteins in the blood are higher in people with type 2 diabetes, which might help doctors understand and treat the disease better.
Methodology
A systematic review and meta-analysis were performed, including 22 studies with a total of 11,953 subjects, assessing serum levels of ERS biomarkers.
Potential Biases
The risk of bias was assessed using the Newcastle–Ottawa scale, with most studies classified as high quality.
Limitations
The primary studies had heterogeneity and limited sample sizes, which may affect the generalizability of the findings.
Participant Demographics
The mean age was 53.5 years, with a male to female ratio of 50:50, and 2224 subjects had type 2 diabetes.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI 1.13–3.46 for HSP70; 95% CI 0.19–1.01 for secretagogin
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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