c-KIT and its ligand in synovial sarcoma
Author Information
Author(s): Tamborini E, Papini D, Mezzelani A, Riva C, Azzarelli A, Sozzi G, Pierotti M A, Pilotti S
Primary Institution: Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
Hypothesis
The over-expression of the c-KIT gene is associated with synovial sarcoma.
Conclusion
The study found that c-KIT expression is modulated in different components of synovial sarcoma, suggesting a role in tumor progression.
Supporting Evidence
- Over-expression of c-KIT was found to be associated with synovial sarcoma.
- c-KIT expression was faint in the spindle cell component and strong in the epithelial component.
- Co-presence of c-Kit and SCF mRNA was observed in almost all cases.
Takeaway
This study looked at a type of cancer called synovial sarcoma and found that a gene called c-KIT is important for how the cancer grows.
Methodology
The study analyzed 23 primary and metastatic samples using immunophenotyping, immunoprecipitations, Western blotting, and RT-PCR.
Participant Demographics
The study included 21 patients with synovial sarcoma.
Digital Object Identifier (DOI)
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