2-(Thiophen-2-yl)ethyl 4-methylbenzenesulfonate
2011
Crystal Structure of a Compound Used in Clopidogrel Synthesis
publication
Evidence: moderate
Author Information
Author(s): Liang Yan-Shu, Liu Bing-Ni, Liu Mo, Liu Deng-Ke
Primary Institution: Tianjin University of Commerce
Conclusion
The crystal structure of the compound shows a dihedral angle of 13.86° between the thiophene and benzene rings, with weak hydrogen bonds linking the molecules.
Supporting Evidence
- The compound is an intermediate in the synthesis of the anti-platelet agent clopidogrel.
- The dihedral angle between the thiophene and benzene rings is 13.86°.
- Weak intermolecular C—H⋯O hydrogen bonds link the molecules into layers.
Takeaway
Scientists studied a special chemical structure that helps make a medicine for heart problems, and they found out how the parts of this structure fit together.
Methodology
The crystal structure was determined using X-ray diffraction techniques.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website