Analysis of KLF transcription factor family gene variants in type 2 diabetes
Author Information
Author(s): Gutiérrez-Aguilar Ruth, Benmezroua Yamina, Vaillant Emmanuel, Balkau Beverley, Marre Michel, Charpentier Guillaume, Sladek Rob, Froguel Philippe, Neve Bernadette
Primary Institution: UMR8090, CNRS, Institute of Biologie/Institute Pasteur de Lille, Lille, France
Hypothesis
KLF genes could be associated with genetic susceptibility for type 2 diabetes (T2D).
Conclusion
It is unlikely that variants in different members of the KLF gene family play a major role in T2D in the French population.
Supporting Evidence
- Three of the 28 SNPs showed a trend to be associated with T2D in the first case-control set.
- Analysis of the second set and combined analysis did not show an association with T2D.
- The study concluded that KLF2, -15, and -16 do not contribute to genetic susceptibility for T2D.
Takeaway
The study looked at genes that might affect diabetes risk but found that they probably don't play a big role in causing diabetes in people from France.
Methodology
Variants of nine KLF genes were genotyped in T2D cases and controls in a two-stage study involving 2,219 individuals.
Limitations
The study may have missed weak associations due to its two-stage design and does not cover all genetic variability of the KLF genes.
Participant Demographics
Participants were of French origin, including T2D patients with a family history and normoglycemic controls.
Statistical Information
P-Value
P < 0.10
Confidence Interval
95% CI = 0.53–1.05 for KLF2, 95% CI = 0.67–1.02 for KLF4, 95% CI = 1.02–1.59 for KLF5
Statistical Significance
p<0.10
Digital Object Identifier (DOI)
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