An Information-Theoretic Characterization of the Optimal Gradient Sensing Response of Cells
2007
Optimal Gradient Sensing in Cells
Sample size: 500
publication
Evidence: high
Author Information
Author(s): Andrews Burton W, Iglesias Pablo A
Primary Institution: The Johns Hopkins University
Hypothesis
How can cells optimally detect the location of an external chemoattractant source in the presence of noise?
Conclusion
Cells that utilize optimal signaling schemes based on prior knowledge of chemoattractant gradients can chemotax more efficiently.
Supporting Evidence
- More accurate chemotaxis requires greater mutual information.
- A priori information can improve chemotaxis efficiency.
- Different observed classes of responses in cells are optimal under varying information assumptions.
Takeaway
Cells need to sense where to go based on chemical signals, and using the right information helps them move better towards food.
Methodology
The study used rate distortion theory to model cellular decision-making processes in response to chemoattractant gradients.
Statistical Information
P-Value
p < 10−9
Statistical Significance
p < 10−9
Digital Object Identifier (DOI)
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