Serum Uric Acid Levels and SLC22A12 Genotype in Japanese
Author Information
Author(s): Hamajima Nobuyuki, Naito Mariko, Hishida Asahi, Okada Rieko, Asai Yatami, Wakai Kenji
Primary Institution: Nagoya University Graduate School of Medicine
Hypothesis
What is the serum uric acid distribution according to the SLC22A12 W258X genotype in a general Japanese population?
Conclusion
The SLC22A12 W258X genotype significantly affects serum uric acid levels, with a wider distribution observed in those with the WX genotype.
Supporting Evidence
- The genotype frequency was 4,793 for WW, 225 for WX, and 5 for XX.
- Mean SUA was significantly different among genotypes, with males showing a larger difference than females.
- Subjects with WX genotype had SUA levels ranging widely from 0.8 mg/dL to 7.8 mg/dL.
Takeaway
This study looked at how a specific gene affects uric acid levels in Japanese people, finding that some people have very low levels while others have much higher levels.
Methodology
The study involved 5,023 health checkup examinees aged 35 to 69 years, genotyping the SLC22A12 W258X allele using PCR.
Limitations
The small number of participants with the XX genotype may not reflect the true distribution, and medication influencing SUA was not accounted for.
Participant Demographics
3,413 males and 1,610 females aged 35 to 69 years.
Statistical Information
P-Value
8E-12
Confidence Interval
[0.021-0.027]
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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