Improving Diabetes Control with Premixed Insulin
Author Information
Author(s): Hak Chul Jang, Serdar Guler, Marina Shestakova
Primary Institution: Seoul National University Bundang Hospital
Hypothesis
Can simple intensification with a modern premixed insulin help patients with type 2 diabetes who are not achieving glycaemic targets with basal insulin?
Conclusion
Patients with type 2 diabetes who are failing to reach glycaemic targets on basal insulin can achieve better glycaemic control without an increase in overall hypoglycaemia by intensifying with BIAsp 30.
Supporting Evidence
- HbA1c was significantly lowered in both groups after treatment with BIAsp 30.
- Reductions in fasting plasma glucose and postprandial plasma glucose were statistically significant.
- The rate of overall hypoglycaemia remained constant in patients switching from analogue basal insulin but decreased in those switching from human basal insulin.
Takeaway
If someone with diabetes isn't getting better with their current insulin, switching to a new type can help them feel better without causing more low blood sugar.
Methodology
This was a 6-month observational study analyzing data from patients previously treated with basal insulin who switched to BIAsp 30.
Potential Biases
The lack of randomization and reliance on physician discretion for treatment adjustments may introduce bias.
Limitations
The study was observational and relied on patient recollection for hypoglycaemia and adverse drug reactions, which may lead to under-reporting.
Participant Demographics
{"gender":{"male":54.7,"female":45.3},"mean_age":56.9,"mean_diabetes_duration":10.4,"mean_weight":72.7,"mean_BMI":27.2}
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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