Protein Functions of Gut Microbes in Thai Infants with Atopic Dermatitis
Author Information
Author(s): Chantanaskul Thanawit, Patumcharoenpol Preecha, Roytrakul Sittirak, Kingkaw Amornthep, Vongsangnak Wanwipa
Primary Institution: Kasetsart University
Hypothesis
This study investigates the protein expression, functions, and interactions of the gut bacteriome and mycobiome in Thai infants with atopic dermatitis.
Conclusion
The study found significant differences in gut microbial composition and protein expression between healthy infants and those with atopic dermatitis.
Supporting Evidence
- Probiotic species like Lactobacillus acidophilus were reduced in infants with atopic dermatitis.
- Pathogenic bacteria such as Streptococcus constellatus increased in abundance in the AD group.
- Functional analysis showed proteins related to stress and DNA repair were enriched in the AD group.
Takeaway
This research shows that the balance of good and bad bacteria in the gut can affect skin conditions like atopic dermatitis in babies.
Methodology
The study used metaproteomic and host interaction analysis to compare protein expression in the gut microbiome of healthy infants and those with atopic dermatitis.
Limitations
The study is limited by its sample size and the specific population of Thai infants, which may not be generalizable.
Participant Demographics
Thai infants with and without atopic dermatitis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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