Possible involvement of endothelin peptides and L-arginine-nitric oxide pathway on the effect of endotoxin in the rabbit isolated perfused kidney
1994
Effects of E. coli Endotoxin on Rabbit Kidney Function
Sample size: 15
publication
Evidence: moderate
Author Information
Author(s): K. Ozsan, R. K. Tırker, Z. S. Ercan
Primary Institution: University of Ankara; Gazi University, Ankara, Turkey
Hypothesis
Does E. coli endotoxin infusion affect kidney flow and weight through endothelin peptides and nitric oxide pathways?
Conclusion
E. coli endotoxin infusion decreases kidney flow and weight, indicating a vasoconstrictor effect mediated by endothelin peptides and nitric oxide.
Supporting Evidence
- LPS infusion caused a significant decrease in kidney flow and weight.
- Endothelin-1 and big endothelin-1 produced similar vasoconstrictor effects.
- Phosphoramidon significantly inhibited the effects of LPS on kidney function.
Takeaway
When rabbits received E. coli endotoxin, their kidneys didn't work as well, which was linked to certain chemicals in their bodies.
Methodology
Isolated perfused kidneys from adult rabbits were used to measure flow and weight changes after LPS infusion.
Participant Demographics
Adult rabbits of both sexes weighing 2.5-3.0 kg.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Want to read the original?
Access the complete publication on the publisher's website