Study of NDE1 and NDEL1 Proteins in Schizophrenia
Author Information
Author(s): Nicholas J. Bradshaw, Sheila Christie, Dinesh C. Soares, Becky C. Carlyle, David J. Porteous, J. Kirsty Millar
Primary Institution: The University of Edinburgh
Hypothesis
NDE1 and NDEL1 proteins interact with DISC1 and may play a role in schizophrenia.
Conclusion
The study reveals that NDE1 and NDEL1 have multiple isoforms and interact with DISC1, suggesting a complex role in neuronal activity and schizophrenia.
Supporting Evidence
- NDE1 and NDEL1 are highly homologous proteins with multiple isoforms present in the brain.
- NDE1 binds directly to multiple isoforms of DISC1 and can self-associate.
- NDE1 and NDEL1 co-associate, indicating a complex interaction in neuronal regulation.
Takeaway
This study found that two proteins, NDE1 and NDEL1, can stick together and also connect with another protein linked to schizophrenia, which might help us understand how these proteins work in the brain.
Methodology
The study involved examining isoforms of NDE1 and NDEL1 in the brain and their interactions with DISC1 using various biochemical techniques.
Limitations
The analysis of isoform expression was not quantitative and used samples from different individuals.
Digital Object Identifier (DOI)
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