E-cadherin gene mutations are rare in adenocarcinomas of the oesophagus
1999
E-cadherin gene mutations in oesophageal adenocarcinomas
Sample size: 49
publication
Evidence: moderate
Author Information
Author(s): Wijnhoven B P L, Both N J de, Dekken H van, Tilanus H W, Dinjens W N M
Primary Institution: Erasmus University Medical Center Rotterdam
Hypothesis
Do genetic events lead to reduced E-cadherin expression in oesophageal adenocarcinomas?
Conclusion
E-cadherin gene mutations are rare in oesophageal adenocarcinomas, despite frequent loss of heterozygosity at the E-cadherin locus.
Supporting Evidence
- Reduced expression of E-cadherin is observed in oesophageal adenocarcinomas.
- 65% of informative cases showed loss of heterozygosity at the E-cadherin locus.
Takeaway
The study looked for changes in a gene called E-cadherin in cancer samples, but found that mutations in this gene are not common.
Methodology
The study screened all 16 exons of the E-cadherin gene for mutations using PCR-SSCP in 49 resection specimens and other samples.
Digital Object Identifier (DOI)
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