Thermo-Sensitive Gels for Eye Drops
Author Information
Author(s): Bhowmik Manas, Das Sanchita, Chattopadhyay Dipankar, Ghosh Lakshmi K.
Primary Institution: Jadavpur University, Kolkata, India
Hypothesis
The study aims to develop thermo-sensitive in-situ gels for ocular delivery of ketorolac tromethamine.
Conclusion
The developed in-situ gels provide a better alternative to conventional eye drops by enhancing drug release and ocular bioavailability.
Supporting Evidence
- The gel temperature of 1% MC solution was observed at 60°C.
- The addition of 6% ORS reduced the gel temperature below physiological levels.
- HPMC increased the viscosity and drug release time of the gels.
- The developed systems showed sustained drug release over a 4-hour period.
Takeaway
Scientists created special gels that turn into a thicker liquid when they get warm, making them better for delivering medicine to the eyes.
Methodology
The study involved formulating in-situ gels using methylcellulose and hydroxypropylmethyl cellulose, and evaluating their gelation temperature, viscosity, swelling, and drug release profiles.
Digital Object Identifier (DOI)
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