Characteristics of Acute Heart Failure with Normal Ejection Fraction and Low BNP Levels
Author Information
Author(s): Shimamoto Ken, Koike Natsuha, Mizuochi Kiyoko, Honma Miho, Kasai Yufuko, Sakai Akiko, Fujita Etsuko, Kawana Masatoshi
Primary Institution: Tokyo Women's Medical University Aoyama Hospital
Hypothesis
What are the characteristics of acute heart failure with normal ejection fraction and modestly elevated B-type natriuretic peptide (BNP) levels?
Conclusion
Acute heart failure with less elevated BNP is associated with a history of open-heart surgery and marked atrial enlargement.
Supporting Evidence
- Patients with a history of open-heart surgery had a significantly lower BNP level.
- The NB group had a higher rate of general malaise and hepatomegaly.
- Left atrial diameter was higher in the NB group compared to the B group.
Takeaway
This study looked at patients with heart failure who had normal heart function and found that those with a history of heart surgery had lower levels of a certain heart-related protein called BNP.
Methodology
The study involved 142 patients with acute heart failure, divided into two groups based on BNP levels, and compared clinical findings and echocardiography results.
Potential Biases
Potential bias due to reliance on historical data and subjective assessments of heart failure severity.
Limitations
The study relied on patient history for pericardial lesions and had limited hemodynamic assessments.
Participant Demographics
77 men and 65 women, ages 33 to 93 years, with a mean age of 73.7 years.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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