Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint
2007
Understanding the Spindle Checkpoint and APC/C Regulation
Commentary
Author Information
Author(s): Díaz-Martínez Laura A, Yu Hongtao
Primary Institution: Department of Pharmacology, University of Texas Southwestern Medical Center
Conclusion
The study suggests a dynamic model for the regulation of APC/C by the spindle checkpoint, highlighting the complex interactions involved.
Supporting Evidence
- The spindle checkpoint prevents premature sister-chromatid separation and mitotic exit.
- Mad3 binds to Cdc20 and inhibits APC/C, which is crucial for proper chromosome segregation.
- Ubiquitination of Cdc20 is necessary for checkpoint inactivation.
Takeaway
This study explains how a protein called Mad3 helps control when cells divide by blocking certain actions until everything is ready, like making sure all the chromosomes are in the right place.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website