Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
2001
Link Between p53 Mutations and COX-2 Overexpression in Gastric Cancer
Sample size: 39
publication
Evidence: moderate
Author Information
Author(s): Leung W K, To K-F, Ng Y-P, Lee T-L, Lau J Y W, Chan F K L, Ng E K W, Chung S C S, Sung J J Y
Primary Institution: Chinese University of Hong Kong
Hypothesis
Is there an association between p53 mutations and COX-2 expression in gastric cancer?
Conclusion
The study suggests a link between p53 mutation and COX-2 overexpression in gastric cancer.
Supporting Evidence
- COX-2 over-expression was seen in 48.7% of gastric cancer cases.
- Tumours with COX-2 overexpression had more lymph-node metastasis.
- Missense mutations of p53 were detected in 51.3% of patients.
Takeaway
This study found that changes in a specific gene (p53) are related to higher levels of another protein (COX-2) in stomach cancer.
Methodology
The study examined the association between p53 mutation and COX-2 expression in gastric cancer patients.
Participant Demographics
Patients with gastric cancer, with 51.3% having p53 mutations.
Statistical Information
P-Value
0.016
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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