3-(2,4-Dimethoxyanilino)-8-methoxydibenz[b,e]oxepin-11(6H)-one
2011
Study of a New Compound with Potential Pharmaceutical Applications
publication
Evidence: moderate
Author Information
Author(s): Baur Benjamin, Schollmeyer Dieter, Laufer Stefan
Primary Institution: Eberhard Karls University Tübingen
Hypothesis
The study aims to synthesize new oxepin derivatives based on dibenzo[b,e]oxepin-11(6H)-one as potential p38 MAP kinase inhibitors.
Conclusion
The synthesized compound exhibits a specific crystal structure characterized by several hydrogen bonds.
Supporting Evidence
- The compound was synthesized in the course of an ongoing study to insert hydrophilic residues at position 8.
- The crystal structure is characterized by several hydrogen bonds.
- The two benzene rings of the tricyclic unit are oriented at a dihedral angle of 37.5°.
Takeaway
Scientists made a new chemical compound that might help in medicine, and they found out how it looks at a tiny level.
Methodology
The compound was synthesized using a palladium-catalyzed amination reaction and characterized through X-ray crystallography.
Digital Object Identifier (DOI)
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