Inflammation and High-Mobility Group Box-1 in Diabetic Retinopathy
Author Information
Author(s): El-Asrar Ahmed M. Abu, Nawaz Mohd Imtiaz, Kangave Dustan, Geboes Karel, Ola Mohammad Shamsul, Ahmad Saif, Al-Shabrawey Mohamed
Primary Institution: King Saud University
Hypothesis
To measure levels of HMGB1 and sRAGE in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR) and correlate their levels with clinical disease activity and inflammatory biomarkers.
Conclusion
Subclinical chronic inflammation might contribute to the progression of proliferative diabetic retinopathy.
Supporting Evidence
- HMGB1 was detected in all vitreous samples.
- Mean HMGB1 levels in PDR with active neovascularization were twofold higher than in inactive PDR.
- Mean levels of MCP-1 and sICAM-1 were higher in active PDR patients than in inactive PDR patients.
Takeaway
This study found that higher levels of certain proteins in the eyes of diabetic patients are linked to more severe eye disease.
Methodology
Vitreous samples from 29 PDR and 17 nondiabetic patients were studied using enzyme-linked immunosorbent assay.
Participant Demographics
24 males and 5 females, ages 30 to 70 years, mean age 46.9 years.
Statistical Information
P-Value
p=0.0111
Confidence Interval
95% CI=1.04–1.26
Statistical Significance
p<0.05
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