High Prevalence of HMOAstV-C in Humans
Author Information
Author(s): Burbelo Peter D., Ching Kathryn H., Esper Frank, Iadarola Michael J., Delwart Eric, Lipkin W. Ian, Kapoor Amit
Primary Institution: National Institute of Dental and Craniofacial Research, National Institutes of Health
Hypothesis
Is HMOAstV-C a prevalent human infectious agent?
Conclusion
HMOAstV-C is a common infectious agent circulating in human populations, with a seroprevalence of approximately 65% in adults.
Supporting Evidence
- 65% of healthy adult US blood donors were seropositive for HMOAstV-C.
- The prevalence of antibodies in children increased with age.
- 50% of infants showed anti-HMOAstV-C antibody responses, likely due to maternal antibodies.
Takeaway
This study found that many adults have antibodies against a virus called HMOAstV-C, which means they have been infected with it. Kids also show some antibodies, but not as many as adults.
Methodology
The study used the Luciferase Immunoprecipitation System (LIPS) to analyze serum samples for antibodies against HMOAstV-C.
Limitations
The study did not include clinical information about the serum donors, which may limit the understanding of the infection's impact.
Participant Demographics
The study included 106 adult healthy blood donors and 103 children from various age groups.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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