Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5
2008
Hepatocyte Growth Factor Boosts Apoptosis in Medulloblastoma Cells
Sample size: 9
publication
Evidence: high
Author Information
Author(s): Li Yang, Fan Xing, Goodwin C Rory, Laterra John, Xia Shuli
Primary Institution: Hugo W. Moser Research Institute at Kennedy Krieger
Hypothesis
Does hepatocyte growth factor (HGF) enhance TRAIL-induced apoptosis in medulloblastoma cells?
Conclusion
HGF enhances TRAIL-induced cell death in medulloblastoma cells by up-regulating the death receptor DR5.
Supporting Evidence
- HGF increased TRAIL-induced cell death by 36%.
- No cell death was observed with HGF alone.
- HGF treatment for at least 24 hours was required to enhance TRAIL-induced cell death.
- HGF up-regulated the expression of the death receptor DR5.
Takeaway
HGF helps brain cancer cells die when treated with a special signal called TRAIL, making it easier to kill these cancer cells.
Methodology
Human medulloblastoma cells were treated with HGF and TRAIL, followed by cell death measurement using MTT and flow cytometry.
Participant Demographics
Human medulloblastoma cell line DAOY was used.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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