ORENZA: A Database for Orphan Enzyme Activities
Author Information
Author(s): Lespinet Olivier, Labedan Bernard
Primary Institution: Institut de Génétique et Microbiologie, CNRS UMR 8621, Université Paris-Sud
Hypothesis
There is a significant gap between known enzyme functions and their associated amino acid sequences in public databases.
Conclusion
ORENZA is a web resource designed to bridge the gap between enzyme activities and their corresponding sequences, facilitating better collaboration between biochemists and genomicists.
Supporting Evidence
- More than 36% of enzyme activities are not associated with any amino acid sequence in major public databases.
- ORENZA allows users to browse and search for specific enzyme activities and their properties.
- The database is designed to be periodically updated with new information.
Takeaway
ORENZA helps scientists find information about enzymes that don't have known sequences, making it easier to connect enzyme functions with the genes that produce them.
Methodology
The ORENZA database was constructed using data from various public databases and organized into a relational database for easy access and querying.
Limitations
The database relies on existing public data, which may be incomplete or outdated.
Digital Object Identifier (DOI)
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