Expression of S100B during embryonic development of the mouse cerebellum
2007
S100B Expression in Mouse Cerebellum Development
publication
Evidence: moderate
Author Information
Author(s): Hachem Sabira, Laurenson Anne-Sophie, Hugnot Jean-Philippe, Legraverend Catherine
Primary Institution: Institut de Génomique Fonctionnelle, Département d'Oncologie Cellulaire et Moléculaire
Hypothesis
The study aims to establish the spatio-temporal pattern of S100B gene expression in the embryonic cerebellum.
Conclusion
The study provides a detailed characterization of S100B-expressing cell types in the embryonic mouse cerebellum.
Supporting Evidence
- S100B was expressed in the primary radial glial scaffold involved in Purkinje progenitor exit from the ventricular zone.
- Transient EGFP expression tagged the Pax6+ forerunners of granule precursors born in the cerebellar rhombic lip.
- The study provides the first characterization of S100B-expressing cell types in the embryonic mouse cerebellum.
Takeaway
This study looks at how a specific protein, S100B, is expressed in the developing brain of mice, helping us understand how brain cells grow and develop.
Methodology
The study used transgenic S100B-EGFP mice to observe S100B expression patterns during embryonic development.
Digital Object Identifier (DOI)
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