Elaeagnus latifolia Fruit Extract Helps Reduce Obesity and Inflammation in Mice
Author Information
Author(s): Munkong Narongsuk, Jantarach Nattanida, Yoysungnoen Bhornprom, Lonan Piyanuch, Makjaroen Jiradej, Pearngam Phorutai, Kumpunya Sarinya, Ruxsanawet Kingkarnonk, Nanthawong Saharat, Somparn Poorichaya, Thim-Uam Arthid, Napolitano Alessandra
Primary Institution: University of Phayao
Hypothesis
The study aimed to evaluate the effects of Elaeagnus latifolia fruit extract on high-fat diet-induced obesity and inflammation.
Conclusion
The study found that Elaeagnus latifolia fruit extract significantly reduced body weight, lipid accumulation, and inflammation in mice fed a high-fat diet.
Supporting Evidence
- Mice given the EL fruit extract had lower body weight compared to those that did not receive it.
- The extract reduced lipid accumulation and oxidative stress in adipocytes.
- Macrophage infiltration in adipose tissue was decreased in mice treated with the extract.
- The extract increased the expression of adipogenic transcription factors.
- Inflammatory cytokine levels were lower in mice treated with the extract.
Takeaway
Giving mice a special fruit extract helped them lose weight and feel better when they ate a lot of fat.
Methodology
Mice were divided into groups and fed either a normal or high-fat diet with or without the fruit extract for 10 weeks, followed by various biochemical and histological analyses.
Limitations
The study did not assess the long-term effects of the extract or its specific phytochemicals on female obesity and adipocyte culture.
Participant Demographics
Four-week-old male ICR mice were used in the study.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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