lncRNA CHAF1B-2 and its role in gastric cancer
Author Information
Author(s): Tian Shao-Qi, Shen Jun-Jie, Sun Dao-Ping, Chen Wen-Ming
Primary Institution: Department of Oncology, Xiyuan Hospital Jining Hospital
Hypothesis
Lnc-CHAF1B-2 contributes to the tumorigenesis of gastric cancer by activating the Wnt/β-catenin pathway.
Conclusion
Lnc-CHAF1B-2 is upregulated in gastric cancer tissues and negatively correlates with patient prognosis.
Supporting Evidence
- Lnc-CHAF1B-2 was significantly upregulated in gastric cancer tissues compared to adjacent noncancerous tissues.
- There was a positive correlation between lnc-CHAF1B-2 levels and the occurrence of distant metastases in patients.
- High expression of lnc-CHAF1B-2 was significantly negatively correlated with overall and disease-specific survival rates of patients.
- Lnc-CHAF1B-2 enhanced the proliferation, invasion, and migration of gastric cancer cells while inhibiting apoptosis.
Takeaway
A molecule called lnc-CHAF1B-2 helps cancer cells grow and spread in stomach cancer, and doctors might use it to help treat patients.
Methodology
The study used bioinformatics analysis, in vivo and in vitro experiments including EdU incorporation, flow cytometry, trans-well migration and invasion assays, and western blot analysis.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 0.844–0.937
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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