Dominating Biological Networks
2011
Understanding Protein Interaction Networks
Sample size: 9141
publication
Evidence: high
Author Information
Author(s): Milenković Tijana, Memišević Vesna, Bonato Anthony, Pržulj Nataša
Hypothesis
BC genes have a topologically central (TC) role in the human PPI network.
Conclusion
The study found that biologically central genes occupy topologically complex and dense regions of the protein-protein interaction network.
Supporting Evidence
- The study found statistically significant enrichment in BC genes of TC nodes.
- GDC outperformed other centrality measures in identifying biologically central genes.
- The combination of GDC and dominating sets captured a significant percentage of drug targets.
Takeaway
This study looks at how important proteins in our body interact with each other and how their connections can help us understand diseases.
Methodology
The study used network-based approaches to analyze protein-protein interaction networks and identify biologically central genes.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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